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However, to be expedient and to work around certain dietary restrictions and aversions, many cancer patients turn to dietary supplements and nutraceuticals to.
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- Nutraceuticals for Cancer Control| Oasis of Hope Hospital
- Nutraceuticals/Supplements and Cancer Prevention: All Hype?
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Nutraceuticals for Cancer Control| Oasis of Hope Hospital
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Large scale clinical studies have demonstrated the efficacy of using tamoxifen, raloxifene, both estrogen receptor antagonists, and fenretinide, a synthetic retinoid, in protecting women from breast cancer.
The report by the Chemoprevention Working Group to the American Association for Cancer Research was a watershed that signaled the acceptance of chemoprevention as a viable alternative means in cancer control. Therefore, it is of interest to explore the possibility of using phytochemicals or other dietary chemicals as chemopreventive agents. Beside, the study of the biological effects of these phytochemicals at cellular level provides the molecular basis for their anti-tumor function and helps to establish the platform for generating more potent chemopreventive and even chemotherapeutic agents.
Apoptosis is involved in a whole array of normal physiological processes, including immune defense, tissue homeostasis and development, and any tilt of the balance between life and death within an organism which can lead to absence or enhancement of diseases. However, apoptosis can be considered as a proactive selfdefense mechanism of a living organism to weed out dysfunctional cells such as the precursors of metastatic cancer cells, without creating secondary oxidative stress due to inflammation. Indeed, defect in apoptosis mechanism is recognized as an important cause of carcinogenesis.
A dysregulation of proliferation alone is not sufficient for cancer formation; a suppression of apoptotic signaling is needed. Flavonoids are a group of more than polyphenolic compounds that occur naturally in foods of plant origin.
Nutraceuticals/Supplements and Cancer Prevention: All Hype?
These compounds possess a common phenylbenzopyrone structure, and they are categorized according to the saturation level and opening of the central pyran ring, mainly into flavones, flavonols, isoflavones, flavonols, flavanone, and flavanonols. Among them, tea polyphenols, quercetin, and genistein have been widely studied for their potential chemopreventive applications. Some flavonoids were first shown to be apoptotic in human lymphoid leukemic cells and human carcinoma cells.
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Similar observations have since been extended to lung tumor cell lines, colon cancer cells, breast cancer cells, prostate cancer cells, stomach cancer cells, brain tumor cells, head and neck squamous carcinoma, and cervical cancer cells. Recent epidemiologic studies have shown good correlation between dietary intake of carotenoids and reduced risk of cancer and cardiovascular diseases.
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Tomato is rich in various carotenoids. Caffeic acid phenethyl ester, an active phenolic component extracted from honey bee propolis, blocks tumorigenesis in a two stage model of mouse skin cancer.
Caffeic acid phenethyl ester has been reported induce apoptosis in HL leukemic cells and mouse epidermal JB6 Cl 41 cells. Curcumin induces apoptosis in colon carcinoma cells, leukemic cells, prostate cancer cells, melanoma cells, and breast cancer cells. The use of garlic as anticancer agent has long been established.